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Botulinum toxin is now widely used in the treatment of several hyperkinetic movement disorders.To evaluate its efficacy in treating muscle cramping syndromes,we studied clinical and neurophysiological variables before and after botulinum toxin injections into calf muscles and small flexor muscles of the foot in patients with an inherited benign cramp-fasciculation syndrome.These findings show that local intramuscular injections of botulinum toxin provide effective,safe,and long-lasting relief of cramps possibly by reducing presynaptic cholinergic stimulation of motor nerve terminals and by impairing the input/output function of intrafusal and extrafusal motor end plates. |
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